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  Citation statistics : Table of Contents
   2016| January-March  | Volume 3 | Issue 1  
    Online since February 1, 2016

 
 
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ORIGINAL ARTICLES
Study of Dyslipidemia and Cystatin C Levels as a Predictive Marker of Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients at a Teaching Hospital in Central India
Kamal Kachhawa, Meena Varma, Poonam Kachhawa, Ankita Sahu, M.K.S. Shaikh, Sanjay Kumar
January-March 2016, 3(1):24-28
DOI:10.4103/2394-2916.175401  
Background and Objective: Diabetic nephropathy is the most common cause of microvascular chronic complication of Type 2 diabetes mellitus (T2DM), which is associated with considerable morbidity and mortality. Chronic kidney diseases (CKD) may result from diabetes mellitus (34%), hypertension (29%), glomerulonephritis (14%), and others (23%). The present study was undertaken to explore the possibility of the serum cystatin C level as a marker of early renal impairment in T2DM patient. Materials and Methods: The study was conducted in 75 patients of T2DM and 75 healthy individuals were included as control in this study. After 12 h fasting, 8 mL venous blood sample was collected and allowed to clot for ΍ h and serum was separated. Lipid profile and cystatin C level of serum were measured by using commercially available kit of auto analyzer. Results: The level of serum cystatin C was significantly increased in T2DM patients as compared to control. In T2DM patients, high-density lipoprotein cholesterol significantly decreased (P < 0.001), while other parameters of lipid profile were significantly increased (P < 0.001) as compared to control group. Conclusion: Present study suggests that cystatin C measurement in serum is a useful, practical, noninvasive tool for the evaluation of renal involvement in the course of diabetes, especially patients, and the study also shows significant lipoprotein abnormalities in T2DM patients when compared to control.
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EDITORIAL
Improving the Renal Profile of a Human Immunodeficiency Virus Drug Combination Through Prodrug Alteration
Derek E Murrell, Sam Harirforoosh
January-March 2016, 3(1):1-2
DOI:10.4103/2394-2916.175388  
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LETTER TO EDITOR
Recurrent Hyperkalemic Renal Tubular Acidosis and Hyponatremia in Diabetes Mellitus due to Aldosterone Resistance
Mansoor C Abdulla, Jemshad Alungal, Ram Narayan
January-March 2016, 3(1):29-30
DOI:10.4103/2394-2916.175403  
  - 2,879 213
ORIGINAL ARTICLES
Spectrum of Ankle-Brachial Index in Chronic Kidney Disease in Rural Teaching Hospital
Shriharsha Ontenddu, Sunil Kumar, Pankaj Banode
January-March 2016, 3(1):19-23
DOI:10.4103/2394-2916.175397  
Background and Objective: The ankle-brachial index (ABI) is a noninvasive method used to predict subclinical atherosclerosis in patients with chronic kidney disease (CKD). Studies regarding this are lacking in India, especially in a rural setting. Here, we have tried to determine the prevalence of peripheral arterial disease (PAD) by manual ABI, which is a low-cost diagnostic tool than Doppler ABI. Materials and Methods: This is a prospective observational study carried out over a period of 2 years enrolling 240 patients with CKD within the age group of 17-85 years. All patients and controls underwent thorough clinical examination and required laboratory investigation. Statistical analysis was carried out using statistics using the Z-test for the difference in comparison and calculation of P values. Results: The mean age of presentation was 47.91 ± 14.23 with a male preponderance of 161 (67.08%). The relation between hemodialysis (HD) and peripheral vascular disease and its duration were compared which showed significantly lower ABI values in patients who were on HD −0.87 ± 0.05 (manual), 0.90 ± 0.09 (Doppler); off HD: 0.89 ± 0.07 (manual), 0.93 ± 0.07 (Doppler) with P = 0.008 (manual), 0.007 (Doppler), and longer duration of HD (>6 months), showing lower ABI values which were statistically significant ≤6 months: 0.88 ± 0.05 (manual), 0.90 ± 0.10 (Doppler); >6 months: 0.85 ± 0.05 (manual), 0.88 ± 0.06 (Doppler). Conclusion: The correlation of both methods of ABI was compared with different stages of CKD in detecting PAD that showed that both methods were equally effective in detecting CKD in different stages.
  - 2,646 217
PERSPECTIVE
A Restricted Understanding of Dr. Xu Songnian's Academic Thoughts
Wenshu Ge, Yueyi Deng
January-March 2016, 3(1):3-7
DOI:10.4103/2394-2916.175392  
This paper introduces academic thoughts and clinical experience of Xu Songnian, a famous modern clinical Traditional Chinese Medicine (TCM) doctor in Shanghai. He studied medical knowledge under Ding Jiwan's guidance. Dr. Ding Jiwan was the descendant of the Zhang Family Internal Medicine. After accumulating clinical experience for a decade, Xu Songnian had concluded unique insights in the treatment of miscellaneous diseases. Dr. Xu put his concentration on the development of renal disease treatment in middle age and gradually formed a set of theoretical system in clinical experience, which made great contribution to the later TCM renal disease development. This paper will give restricted understanding of Dr. Xu's academic thoughts and make a brief introduction of it.
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REVIEW ARTICLES
Clinical Characteristics of Antineutrophil Cytoplasmic Antibodies Associated Vasculitis in the Elderly
Qiang He, Lina Shao
January-March 2016, 3(1):8-13
DOI:10.4103/2394-2916.175393  
Antineutrophil cytoplasmic antibodies (ANCAs) associated vasculitis is a necrotizing vascular inflammation, usually involving multiple organs. It is one of the major diseases that cause deterioration of renal function rapidly in the elderly. The latest Chapel Hill Consensus Conference 2012 has updated the name of ANCA-associated vasculitis. Some high quality randomized clinical trials provide the evident basis for the treatment of vasculitis. However, elderly patients often suffer complex diseases, and are associated with underlying diseases, so it is difficult to be diagnosed and treated. It is very important to make optimized individual strategies of treatment for elderly patients with vasculitis.
  - 3,035 251
Precise Transurethral Enucleation of Prostate: New Surgery Treatment for Benign Prostate Hyperplasia
Huan Xu, Meng Gu, Qi Chen, Yan-bo Chen, Zhi-kang Cai, Zhong Wang
January-March 2016, 3(1):14-18
DOI:10.4103/2394-2916.175395  
There have been many advances in the surgical treatment for benign prostate hyperplasia (BPH), moving from open surgery (retropubic and suprapubic open prostatectomy) to transurethral resection of the prostate (TURP, the historical gold standard and still the most commonly used approach), and onto endoscopic transurethral enucleation. The application of new laser and plasma technologies now allows the precise transurethral enucleation of the prostate (PTUEP). In our medical center, we have found great success using PTUEP. Many urologists have found that PTUEP reduces perioperative complications and risks during operation. It can be applied to all size prostates and can even be used with BPH patients taking anticoagulation medicine. PTUEP is quickly replacing TURP as an effective and less invasive approach to BPH surgery.
  - 4,422 347