Journal of Integrative Nephrology and Andrology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 1  |  Issue : 2  |  Page : 60--66

Prognostic Significance of Cardiac Troponin-T Level in Chronic Kidney Disease Patients on Hemodialysis


Munna Lal Patel1, Rekha Sachan2, Pankaj Singh1, Shyam Chand Chaudhary1, Pushplata Sachan3, Pooja Gupta2 
1 Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India
2 Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, Uttar Pradesh, India
3 Department of Physiology, Career Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
Munna Lal Patel
Department of Medicine, King George Medical University, C-28, Sec-J Aliganj, Lucknow - 226 024, Uttar Pradesh
India

Background: Cardiovascular complications are a major cause of mortality in chronic kidney patients (CKD) patients. More than 50% of patients of end-stage renal disease (ESRD) die due to these complication. Patients undergoing chronic hemodialysis (HD) presented with frequently elevated baseline values of cardiac troponin T (cTnT). Aim of the Study: The aim of this study was to estimate the level of cTnT in ESRD patients and to evaluate its diagnostic and prognostic value in HD patients. Materials and Methods: This was a case-control study carried over a period of 14 months. One hundred and one cases of CKD stage-V as per the KDIGO guidelines 2012 with eGFR ≤15 mL/min and 50 healthy control age-matched with a GFR ≥60 mL/min were included in the study. cTnT levels were measured at the start of the study, at 48 h and 6 months after completion of hemodialysis. Results: The mean age of the controls and cases were 45.74 ± 9.99 years and 47.77 ± 17.53 years, respectively. Of 101 cases, 40 cases had cTnT levels <0.01 ng/L, 16 cases had cTnT levels 0.01-0.029 ng/mL, 20 cases had cTnT levels 0.03-0.099 ng/mL and 25 cases were had cTnT levels >0.10 ng/mL. Cardiac events were observed in 20 patients. Three patients died due to myocardial injury (cTnT levels >0.10 ng/mL) and 17 patients experienced cardiovascular events. These cardiovascular events were sudden cardiac deaths, stroke, atrial-ventricular block and congestive heart failure. Conclusion: All patients on chronic hemodialysis should be evaluated for annual measurement of serum cTnT, which could be used as a reference point. A small increase over time is common, but if any time levels more than double the baseline, which is uncommon, and if found indicate an acute coronary syndrome.


How to cite this article:
Patel ML, Sachan R, Singh P, Chaudhary SC, Sachan P, Gupta P. Prognostic Significance of Cardiac Troponin-T Level in Chronic Kidney Disease Patients on Hemodialysis.J Integr Nephrol Androl 2014;1:60-66


How to cite this URL:
Patel ML, Sachan R, Singh P, Chaudhary SC, Sachan P, Gupta P. Prognostic Significance of Cardiac Troponin-T Level in Chronic Kidney Disease Patients on Hemodialysis. J Integr Nephrol Androl [serial online] 2014 [cited 2021 Feb 25 ];1:60-66
Available from: http://www.journal-ina.com/article.asp?issn=2394-2916;year=2014;volume=1;issue=2;spage=60;epage=66;aulast=Patel;type=0