%A Dineshkumar, Thanigachalam %A Dhanapriya, Jeyachandran %A Murugananth, Subramaniam %A Surendar, Dhanikachalam %A Sakthirajan, Ramanathan %A Rajasekar, Dhanasekaran %A Balasubramaniyan, T %A Gopalakrishnan, Natarajan %T Snake envenomation-induced acute interstitial nephritis %9 Original Article %D 2018 %J Journal of Integrative Nephrology and Andrology %R 10.4103/jina.jina_27_17 %P 14-17 %V 5 %N 1 %U http://www.journal-ina.com/article.asp?issn=2394-2916;year=2018;volume=5;issue=1;spage=14;epage=17;aulast=Dineshkumar %8 January 1, 2018 %X Background and Objectives: Acute kidney injury (AKI) is one of the major complications of snake envenomation, especially in the developing countries. The most common renal histology in snakebite-induced AKI is acute tubular injury (ATI), but acute interstitial nephritis (AIN) is rarely reported. Materials and Methods: We did a prospective observational study between January 2012 and May 2017 to analyze the demographic, clinical, and laboratory data, response to treatment, and outcome of patients with snakebite-induced AIN. Results: About twenty patients were included in the study with mean follow-up of 24 ± 6 months. Of them, 6 (30%) were males. Mean age was 50.9 ± 22.1 years. All the patients received anti-snake venom. AKI developed after a mean duration of 24.1 ± 11.2 h and 15 patients were oliguric. Cellulitis was seen in 65% of patients, anemia in 65%, leukocytosis and thrombocytopenia in 40%, and coagulopathy in 80%. Mean peak serum creatinine was 7.8 ± 3.2 mg/dL. Peripheral eosinophilia was seen in 7 (35%) patients. All the patients were managed with hemodialysis and all except one received oral steroids. Six patients (30%) progressed to chronic kidney disease (CKD) with mean follow-up creatinine of 1.49 ± 0.8 mg/dL. Conclusion: It is prudent to do renal biopsy in patients with snakebite-induced AKI when there is a suspicion of pathology other than ATI. Identification and treatment of AIN with steroid will avoid progression to CKD which has an impact on growing health burden in tropical countries. %0 Journal Article %I Wolters Kluwer Medknow Publications %@ 2394-2916