RT - Journal TY - JOUR A1 - Wang, Yifan A1 - Chen, Haiyong T1 - Ferroptosis in diabetic nephropathy: A narrative review YR - 2014/1/1 JF - Journal of Integrative Nephrology and Andrology JO - J Integr Nephrol Androl SP - 1 OP - 1 VO - 1 IS - 1 UL - http://www.journal-ina.com/article.asp?issn=2394-2916;year=2014;volume=1;issue=1;spage=1;epage=1;aulast=Wang;t=5 DO - 10.4103/imna.imna_2_22 N2 - The prevalence of diabetes has been sharply increasing over the past few decades. Approximately 20%–30% of patients with diabetes progress to evident nephropathy. Kidney cell deaths, for example, ferroptosis, pyroptosis, and apoptosis, are associated with diabetic nephropathy (DN). Ferroptosis is a novel regulated cell death characterized by the increase of oxidative stress and iron-dependent lipid peroxidation. Laboratory or clinical findings indicate that ferroptosis plays an important role in the pathogenesis of DN. This review aimed to summarize the mechanisms of ferroptosis and relevant signaling pathways in DN and provide perspectives and clinical strategies for attenuating ferroptosis-associated DN. ER -