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| LETTER TO EDITOR |
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| Year : 2020 | Volume
: 7
| Issue : 1 | Page : 20 |
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To study the prevalence of thyroid disorders in chronic renal disease patients
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
| Date of Submission | 29-May-2019 |
| Date of Decision | 15-Nov-2019 |
| Date of Acceptance | 25-Nov-2019 |
| Date of Web Publication | 24-Aug-2021 |
Correspondence Address:
Prof. Mahmood Dhahir Al-Mendalawi
P. O. Box 55302, Baghdad PostOffice, Baghdad
Iraq
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jina.jina_8_19
How to cite this article:
Al-Mendalawi MD. To study the prevalence of thyroid disorders in chronic renal disease patients. J Integr Nephrol Androl 2020;7:20 |
Dear Editor,
I read an interesting study by Gupta et al.[1] published in October–December 2018 issue of the Journal of Integrative Nephrology and Andrology. On applying thyroid function tests (TFTs), the authors studied thyroid disorders and the correlation between thyroid dysfunction (TD) and severity of renal diseases in a cohort of Indian patients with chronic kidney disease (CKD). They found that 53% had TD, and the prevalence of subclinical hypothyroidism and clinical hypothyroidism was 33% and 20%, respectively. Moreover, there was a significant association between CKD progression and TD.[1] I assume that such results must be cautiously interpreted. This is based on the presence of the following methodological limitations. In the methodology, the authors explicitly mentioned that “blood samples were collected from the participants and were analyzed for free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone by electrochemiluminescence technique using the kits by ADVIA Centaur XP analyzer system of Siemens (Siemens Healthineers limited, Siemens healthcare GmbH, Henkestr, 127, 91052 Erlangen, Germany).”[1] It is obvious that interpreting the values of TFTs in a particular population requires reference intervals for that population. Really, certain populations-specific TFTs reference ranges have been constructed.[2],[3],[4] To my knowledge, India has already established the mean reference intervals for TFTs for different age groups for both genders separately to be applied in the researches and clinical setting.[5] Gupta et al.[1] regrettably did not address which reference norms of TFTs were employed in the study methodology. I assume that employing national reference values could better determine the profile of TD in CKD patients. Despite the above-mentioned limitation, the high prevalence of TD (53%) reported by Gupta et al.[1] urges the need to periodically evaluate thyroid function in CKD patients to preserve renal function.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | |  |
| 1. | Gupta UN, Jain A, Prakash P, Agrawal P, Kumar R, Farooqui M. To study the prevalence of thyroid disorders in chronic renal disease patients. J Integr Nephrol Androl 2018;5:126-9.  [Full text] |
| 2. | Jammah AA, Alshehri AS, Alrakhis AA, Alhedaithy AS, Almadhi AM, Alkwai HM, et al. Characterization of thyroid function and antithyroid antibody tests among Saudis. Saudi Med J 2015;36:692-7. |
| 3. | Mirjanic-Azaric B, Avram S, Stojakovic-Jelisavac T, Stojanovic D, Petkovic M, Bogavac-Stanojevic N, et al. Direct estimation of reference intervals for thyroid parameters in the republic of Srpska. J Med Biochem 2017;36:137-44. |
| 4. | Park SY, Kim HI, Oh HK, Kim TH, Jang HW, Chung JH, et al. Age- and gender-specific reference intervals of TSH and free T4 in an iodine-replete area: Data from Korean National Health and Nutrition Examination Survey IV (2013-2015). PLoS One 2018;13:e0190738. |
| 5. | Marwaha RK, Tandon N, Ganie MA, Mehan N, Sastry A, Garg MK, et al. Reference range of thyroid function (FT3, FT4 and TSH) among Indian adults. Clin Biochem 2013;46:341-5. |
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