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ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 3  |  Page : 81-84

Clinical and Histological Profile of Lupus Nephritis Patients Attending in a Tertiary Care Center


1 Department of Internal Medicine, Chattagram Maa Shishu O General Hospital, Chittagong, Bangladesh
2 Department of Cardiology, Chittagong Medical College, Chittagong, Bangladesh

Correspondence Address:
Rajat Sanker Roy Biswas
Chattagram Maa Shishu O General Hospital, Chittagong
Bangladesh
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2225-1243.161430

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Background and Objectives: Lupus nephritis (LN) is one of the serious manifestations of systemic lupus erythematosus (SLE). It has diversities of clinical and histological presentations. Hence, the main objective of this study is to sort out the clinical and histological varieties of LN in a tertiary care setting of Bangladesh. Materials and Methods: For the study, 30 patients of SLE with renal involvement were selected. Diagnosis of SLE was done on the basis of American Rheumatological Criteria (ACR). After consent, all patients were undergone renal biopsy and tissue was analyzed for histological type and presence or absence of immunoglobulin were also analyzed by direct immuneflurescence study. Data after compilation analyzed by SPSS version 20. Results: All the patients found to have LN were female and most (73.2%) of the patients were at child bearing age between 21 and 40 years. Anti-ds DNA was positive among all (100%) patients and antinuclear antibody was positive among 19 (63%). Among all patients 6 (20%) had ≥3 g proteinuria. The common histological type was found class IV, which was 40% of total patients. A patient of LN found to have histological feature of acute glomerulonephritis. Conclusion: In conclusion, it can be said that LN have varied clinical profile with different histological types.


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