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REVIEW ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 3  |  Page : 75-80

Renal Tubulointerstitial Fibrosis: A Review in Animal Models


1 Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
2 Laboratory of Renal Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
3 Department of Nephrology; Laboratory of Renal Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China

Correspondence Address:
Wen Peng
Department of Nephrology, Laboratory of Renal Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 LanXi Road, Shanghai 200062
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2225-1243.161428

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Deterioration of renal function is closely related to renal interstitial fibrosis (RIF). With animal models, we can simulate the pathological changes and progression of disease. Various animal models of RIF are pivotal for clinical treatment and investigation of new drugs. Reviewed here are methods of establishment and mechanism of commonly used animal models of RIF to help researchers select the optimal animal model for different research purposes.


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