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REVIEW ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 1  |  Page : 19-22

Recent advances of Wnt signaling in kidney diseases


1 Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2 Laboratory of Renal Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Correspondence Address:
Hao Wang
Department of Nephrology, Laboratory of Renal Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 LanXi Road, Shanghai - 200 062
China
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Source of Support: This work was supported by General Medicine of Key Discipline Construction Project, State Administration of Traditional Chinese Medicine of the People’s Republic of China; Leading Academic Discipline Project of State Administration of Traditional Chinese Medicine of China, Talent Project of Integrative Medicine of Shanghai Municipal Health Bureau (ZYSNXD012-RC-ZXY); Key Medical Discipline Project of Shanghai Municipal Health Bureau (ZK2012A34); Independent Innovation Research Fund of Putuo District Science and Technology Committee (2012PTKW002) ; Budget Project of Shanghai Municipal Education Commission (2012JW71) and Putuo Hospital Fund (2013SR123I, 2013GQ007I). Confl ict of Interest: No., Conflict of Interest: None


DOI: 10.4103/2225-1243.150001

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Kidney diseases are a serious hazard to human health, and many different molecular signaling pathways are involved in the complex pathogenesis. Recently the Wnt signaling pathway, one of the most conserved intercellular signaling cascades, has been considered as an effective regulator in various kidney diseases, including ischemic kidney injury, glomerular diseases, diabetic nephropathy, interstitial fibrosis and cystic kidney diseases. Besides, more and more evidence have suggested that the altered Wnt signaling pathway is correlated with the pathological process of kidney diseases, which might offer a novel therapeutic strategy. Therefore, to enhance understanding, here we reviewed the major roles of Wnt signaling cascades and their roles in kidney diseases.


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