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ORIGINAL ARTICLE
Year : 2014  |  Volume : 1  |  Issue : 1  |  Page : 44-47

A study of acute renal failure in patients associated with acute liver dysfunction at vims combined hospital


1 Department of Medicine, Rajarajeshwari Medical College Hospital, Bangalore, India
2 Department of Medicine, Vijayanagar Institute of Medical Sciences, Bellary, India
3 Department of Pharmacology, Sri Devaraj Urs Medical College, Tamaka, Kolar 563101, Karnataka, India
4 Department of Medicine, Basaveshwara Medical College and Hospital, Chitradurga, India

Correspondence Address:
Basavareddy Asha
Department of Pharmacology, Sri Devaraj Urs Medical College, Tamaka, Kolar 563101, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2225-1243.137554

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Background and Objectives: Renal dysfunction is common in liver diseases, either as part of multi-organ involvement in acute illness or secondary to advanced liver disease. The presence of renal impairment in both groups is a poor prognostic indicator. The main aim of the current study is to find out the etiology, clinical features, and incidence of patients who develop both acute liver failure and acute renal failure (ARF). Materials and Methods: This is a prospective observational study conducted for patients admitted in VIMS combined hospital from December 2010 to June 2012. All the patients with both ARF and acute liver dysfunction who met the inclusion criteria were included in the study. Data were collected after obtaining informed/written consent from patient. After detailed history, detailed clinical examination, general physical and systemic examination and relevant laboratory investigations were done. Results: Studies showed that the maximum number of patients were in the age group of 21-30 years with increased incidence in males, farm workers, lower income group. Most patients presented with nonspecific symptoms like fever and myalgia with more than 90% patients had abnormal urine findings and ultrasound findings implying the need for simple investigations to identify this fatal condition. This study had an overall mortality of 26.67%, with the highest mortality noted in patients with septicemia. Conclusion: Our study shows leptospirosis, malaria and sepsis as common causes of combined hepatic and renal dysfunction in this part of the country. Acute cases had a comparatively better prognosis and outcome than chronic cases of combined hepatic and renal dysfunction. Early diagnosis and apt treatment will reduce mortality.


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