Home Current issue Ahead of print Search About us Editorial board Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 677
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2014  |  Volume : 1  |  Issue : 1  |  Page : 20-23

Comparison of seven kinds of calculation methods on glomerular filtration rate in patients with chronic kidney disease


Department of Nephrology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China

Correspondence Address:
Niansong Wang
Department of Nephrology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2225-1243.137547

Rights and Permissions

Objective: The objective was to compare the diagnostic value of seven kinds of calculation methods on glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD). Materials and Methods: A total of 120 cases with CKD and 120 normal people were included in this study. They were grouped according to the GFR results estimated by the plasma clearance of 99m technetium-diethylene-triamine-pentaacetate. Serum cystatin C (Cys C) concentrations were detected by enzyme-linked immunosorbent assay. GFR and serum creatinine (SCr) was simultaneously analyzed using Automatic Biochemistry Analyzer. Estimated GFR (eGFR) was detected with seven kinds of calculation methods. Results: Modification of diet in renal disease (MDRD) equations obtained significantly lower GFR in group CKD2, while Cockcroft-Gault (CG) equation obtained significantly lower GFR in group CKD3. There were no statistical differences between four Cys C-based equations (GFR estimated via cystatin [Cys-eGFR] formula) and GFR from CKD1 to CKD5. In the groups CKD2 and CKD3, GFRs detected by four kinds of formula Cys-eGFR were all superior to that by CG and MDRD. For the CKD patients with GFR <60 mL/min/1.73 m 2 , four kinds of receiver operating characteristic (ROC) curve area of Cys-eGFR were more than GFR estimated via creatinine (Cr-eGFR) formula, the differences were statistically significant. For those with GFR <30 mL/min/1.73 m 2 , the comparative results of ROC curve area had no statistical difference. Conclusion: Cys-eGFR is a more accurate equation for estimating GFR than CG and MDRD equation, but not superior to Cr-eGFR, which based on SCr in advanced chronic renal failure patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2269    
    Printed63    
    Emailed1    
    PDF Downloaded305    
    Comments [Add]    

Recommend this journal