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MINI REVIEW
Year : 2014  |  Volume : 1  |  Issue : 1  |  Page : 11-13

Elevated uric acid levels as another cause of erectile dysfunction: Hypothesis and rationale?


Department of Internal Medicine, Division of Nephrology, Konya Numune State Hospital, Konya 42690, Turkey

Correspondence Address:
Baris Afsar
Department of Nephrology, Konya Numune State Hospital, Ferhuniye Mahallesi, Hastane Caddeleri, Konya 42690
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2225-1243.137543

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Elevated uric acid (UA) levels has been shown to be associated with cardiovascular disease such as hypertension, coronary heart disease, heart failure, renal failure, peripheral vascular disease, metabolic syndrome, and stroke. In addition, in recent years various novel pathological entities such as endothelial dysfunction, oxidative stress, inflammation, activation of the renin angiotensin system (RAS) has been found to be associated with increased UA levels. Erectile dysfunction (ED) on the other hand has also been associated with cardiovascular risk. Besides, similar mechanisms such as endothelial dysfunction, oxidative stress and RAS have been found to be related with ED. Thus, the current hypothesis tried to explain why UA may be associated with ED.


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